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ehd123 ehd123
wrote...
Valued Member
Posts: 778
Rep: 54 2
9 years ago
Why is sublethal irradiation an important step in stem cell experiments? especially when the scientists are studying the expression of proteins like oct4 and sox2?

is the high expression of these proteins in a small fraction of cells because of irradiation?
Shouldn't these expressions be high is more cells?

thank you for the help Slight Smile
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B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience

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wrote...
#1
Educator
9 years ago
1) http://www.ncbi.nlm.nih.gov/pubmed/10463763

2) http://www.informatics.jax.org/greenbook/chapters/chapter22.shtml

And some references below. For the first attachment, it states:

Quote
After sublethal irradiation, the restoration process in hemopoietic tissue may be
considered to consist of two major phases, "early" and "late" repair (1). Early
repair, which occurs during the first day after irradiation, is probably primarily
the result of an intracellular process of recovery which takes place in sublethally
damaged cells, in the absence of cellular proliferation. This recovery process has
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