× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
a
5
k
5
c
5
B
5
l
5
C
4
s
4
a
4
t
4
i
4
r
4
r
4
Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
New Topic  
ehd123 ehd123
wrote...
Valued Member
Posts: 778
Rep: 54 2
9 years ago
Could someone please explain the difference between patch clamp and voltage clamp techniques used in neuroscience studies?

Many thanks
Read 518 times
2 Replies
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience

Related Topics

Replies
wrote...
#1
9 years ago
Unlike traditional two-electrode voltage clamp recordings, patch clamp recording uses a single electrode to record currents. Many patch clamp amplifiers do not use true voltage clamp circuitry but instead are differential amplifiers that use the bath electrode to set the zero current level. This allows a researcher to keep the voltage constant while observing changes in current. Alternatively, the cell can be current clamped in whole-cell mode, keeping current constant while observing changes in membrane voltage.

[Animation] - The Patch Clamp Method
ehd123 Author
wrote...
#2
Valued Member
9 years ago
Thank you so much =)
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience
New Topic      
Quick Reply
Explore
Post your homework questions and get free online help from our incredible volunteers
  1271 People Browsing
 124 Signed Up Today
Start New Topic Take the Tour CoursesNew Study Tools Topics Trending Browse by Textbook
Related Images
  
 252
  
 887
  
 244
Your Opinion
Which of the following is the best resource to supplement your studies:
Votes: 249
Previous poll results: Which industry do you think artificial intelligence (AI) will impact the most?