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Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
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ehd123 ehd123
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9 years ago Edited: 9 years ago, ehd123
Upon reading about nicotinic acetylcholine receptors families, some with specific subunits were involved with nicotine self-administration. These were referred to in brain imagining studies in smoking patients. What is meant by self-administration?


Also, could someone please provide an animation or short video explaining how nicotinic acetylcholine receptors work? Slight Smile

Many thanks
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4 Replies
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience

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wrote...
#1
Educator
9 years ago
Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself.

Animal self-administration experiments are typically performed in standard operant conditioning chambers adapted for the catheters used to deliver a drug intravenously. The catheter is secured to the animal by a harness or back plate and is tethered to a protective leash that extends upward through a hole in the top of a chamber, where it attaches to a rotating swivel on a mechanical arm that allows the subject to move around freely. The chamber houses two levers: one whose depression results in the delivery of a drug, the other whose depression does nothing. Activity on these levers can be used to measure drug administration (via activity at the drug-inducing lever) as well as changes in nonspecific behavior that reflect short- and long-term effects of the drug (via activity at the non-inducing lever). The sterile intravenous catheter used to deliver the drug into the bloodstream of the subject is typically composed of a flexible plastic, silastic tubing and nylon mesh placed subcutaneously. It is attached to a mechanical pump that can be calibrated to deliver a specific amount of drug upon depression of one of the levers in the chamber. Other chamber modifications are required if the drug is to be delivered orally or via inhalation, such as liquid containers or an aerosol distribution mechanism.

Source  http://en.wikipedia.org/wiki/Self-administration
wrote...
#2
Educator
9 years ago
Not my favourite, but really the only thing available on the internet after conducting an immediate search.



Skip to 2:00 minutes.
wrote...
#3
Educator
9 years ago
Here's to better your understanding as well.
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ehd123 Author
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#4
Valued Member
9 years ago
Thank you =)
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience
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