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ChimpMilk ChimpMilk
wrote...
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6 hours ago
hey everyone,

I was bored today so for shits and giggles i compiled the same TCF7L2 sequence for 4 animals off of the NIH ( African Elephant, Emu, Saltwater croc and anole lizard) to compile into one FASTA file and then run through a phylogenetic analysis. Expecting to find the archosaurs to group together, i actually found that the elephant and emu grouped instead, with crocodiles sometimes being the outgroup to the others or sometimes forming a sister clade to the anoles. Theres a very good chance i just fucked up the process but i tried several different approaches ( Maximum Likelihood/Parsimony etc) but assuming i didnt  I was wondering why this is and did some digging, but only got some unsatisfying results so far. Apparently TCF7L2 is associated with a signaling pathway known as "Wnt" which can control anything from glucose levels (which may be tied to metabolic rate, so grouping of endotherms (?)) and heat based sexual determination ( as seen in crocs) but i kinda hit a wall. Anyone know any good sources or explanations for this or could point me in the right direction? thanks ! Smiling Face with Open Mouth





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Educator
An hour ago
Not to derail your discovery, but this could be a case of convergent evolution, where distantly related organisms evolve similar traits independently. The fact that  these animals are so different yet share something like this in common is a no starter for me... why choose these animals in the first place?

Wish I could look into this further, but currently on vacation, so I can't dig any deeper
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