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a-aminoadipic semialdehyde synthase

Description
These two reactions are catalyzed by a bifunctional enzyme named a-aminoadipic semialdehyde synthase.

The mammalian enzyme is a single protein composed of separate domains for the two catalytic activities.

Although this process uses a-ketoglutarate as the amino acceptor, and produces glutamate, it is more similar to the argininosuccinate synthetase–argininosuccinase reactions of the urea cycle than to a transamination.
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