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Another class of dihydrofolate reductase inhibitors is exemplified by trimethoprim
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Description
This compound is a specific inhibitor of dihydrofolate reductases of prokaryotic origin.

Trimethoprim and its relatives are widely used to treat both bacterial infections and certain forms of malaria.

The success of these drugs derives from their being extremely weak inhibitors of vertebrate dihydrofolate reductases.

Trimethoprim is often administered in conjunction with a sulfonamide drug to inhibit the synthesis of folate and hence to block sequential steps in the same pathway.
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