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SlideshowReport

A model for RecA-mediated strand exchange

Description
At the left, a RecA–ssDNA filament, with ssDNA shown in red.

In the middle, a joint molecule, with triplestranded DNA; the original ssDNA is wrapped in the minor groove of the duplex DNA.

At the right, strand exchange is occurring.

The red ssDNA is complementary in sequence to the yellow strand of the duplex, and RecA action is displacing the green strand, coincident with formation of a new red–yellow dsDNA.
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