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SlideshowReport

A schematic view of delivery of a protein, synthesized in cytoplasm, into the nucleus

Description
A protein with a nuclear localization signal (NLS) binds to importin.
The complex binds to a nuclear pore and passes through.
Within the nucleus Ran-GTP binds to the importin-cargo complex and displaces the cargo.
The resultant Ran-importin complex is returned to the cytoplasm, where Ran-bound GTP is hydrolyzed to GDP.
Ran-GDP returns to the nucleus, and its bound GDP is exchanged for GTP (not shown).
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