Top Posters
Since Sunday
a
5
k
5
c
5
B
5
l
5
C
4
s
4
a
4
t
4
i
4
r
4
r
4
SlideshowReport

A schematic view of delivery of a protein, synthesized in cytoplasm, into the nucleus

Description
A protein with a nuclear localization signal (NLS) binds to importin.
The complex binds to a nuclear pore and passes through.
Within the nucleus Ran-GTP binds to the importin-cargo complex and displaces the cargo.
The resultant Ran-importin complex is returned to the cytoplasm, where Ran-bound GTP is hydrolyzed to GDP.
Ran-GDP returns to the nucleus, and its bound GDP is exchanged for GTP (not shown).
Related Images
Add Comment
Explore
Post your homework questions and get free online help from our incredible volunteers
  1251 People Browsing
 122 Signed Up Today
Your Opinion
Who's your favorite biologist?
Votes: 586