utation acquisition in familial adenomatous polyposis

Mutation acquisition in familial adenomatous polyposis. FAP features the development of hundreds of colonic polyps that can become cancerous. Mutational analysis identifies at least four genes that are frequently, but not universally, mutated as polyps progress toward malignancyMutation acquisition in familial adenomatous polyposis. FAP features the development of hundreds of colonic polyps that can become cancerous. Mutational analysis identifies at least four genes that are frequently, but not universally, mutated as polyps progress toward malignancy

Normal colon epithelium Abnormal proliferation of epithelium Benign adenoma (polyp) Intermediate adenoma DCC Late adenoma : with villi TP$3