Selected Cancers with Inherited Predisposition

Table C.2 Selected Cancers with Inherited Predispositions Cancer Type Predisposing Gene Mutationa Early-onset familial breast BRCA1, BRCA2 cancer Familial adenomatous APC polyposis Familial melanoma CDKN2 Gorlin syndrome PTCH 1 Lynch syndrome MSH2, MSH6 Li—Fraumeni syndrome TP53, CHEKZ Multiple endocrine MEN1 neoplasia, type 1 Multiple endocrine RET neoplasia, type 2 Neurofibromatosis, type 1 NF 1 Neurofibromatosis, type 2 NF2 Retinoblastoma RB1 Von Hippel—Lindau VHL syndrome Wilms tumor WT1 8Go to http://www.ncbi.nlm.nih.gov/omim and enter the gene abbrevia- tion in the Search box at the top of the page to get gene identity and information on gene function and mutations.