The actions of chromatin-remodeling complexes

The SWI/SNF family opens chromatin structure and helps initiate transcription by either displacing nucleosomes away from regulatory sequences or ejecting nucleosomes.  ISWI assembles and organizes nucleosomes in a regular pattern and contributes to transcription repression. SWR1 inserts the modified histone protein H2A.Z into nucleosomes to help facilitate displacementThe SWI/SNF family opens chromatin structure and helps initiate transcription by either displacing nucleosomes away from regulatory sequences or ejecting nucleosomes.  ISWI assembles and organizes nucleosomes in a regular pattern and contributes to transcription repression. SWR1 inserts the modified histone protein H2A.Z into nucleosomes to help facilitate displacement

Transcription activator Nucleosome N l A displacement UC eosome ACT—w SWVSNF ACT SWVSNF family assembly and T ‘ 0 organization A . . ., Nucleosome ejection Histone H2A.Z insertion