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Molecular features of homeotic genes and proteins

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(a) A homeotic gene (shown mostly in light green) contains a 180-bp sequence called the homeobox (shown in dark blue). (b) Homeotic genes encode proteins that function as transcription factors. The homeobox encodes a region of the protein called a homeodomain, which functions in binding to the DNA at a regulatory site, such as an enhancer. The transcriptional activation domain governs the assembly of RNA polymerase components such that transcription can occur.
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