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SlideshowReport

Mutations in cis-regulatory elements of Ultrabithorax cause homeotic transformations

Description
(a) U/trabithorax gene 5W mRNA AAAA DNA h: —40 +1 +50 Cis—regulatory deletion mutations p bx — : : bxd bx abx Cis—regulatory elements: i E i E pf3x bxd blx abx Promotes be Promotes be expression in expression in posterior T3 anterior T3 (b) be+ bebx bePbX T2 Anterior T2 T2 \ Posterior T3 Anterior T3 _ T3 Haltere 326 K \ W \p ' L \ - f” \ osterlor Anterior part of T3 Posterior part of T3 transformed into T2 transformed into T2 +100 kb bebx pbx T2 gs T3 _ Entire T3 transformed into T2
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