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Some inhibitors of transcription

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Rifampicin is an inhibitor of bacterial transcription initiation.

a-amanitin is an inhibitor of eukaryotic RNA polymerases.

Cordycepin is a transcription terminator because the 3’ position on the sugar is occupied by H, rather than a hydroxyl group.

The tricyclic ring system of actinomycin intercalates between adjacent G-C base pairs in DNA; the R groups of the molecule are cyclic polypeptides and fill in the narrow grooves of the helix.
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