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Humulin, a recombinant form of human insulin

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(a) Humulin, a recombinant form of human insulin, was the first therapeutic protein produced by recombinant DNA technology to be approved for use in humans. (b) To synthesize recombinant human insulin, synthetic oligonucleotides encoding the insulin A and B chains were inserted (in separate vectors) at the tail end of a cloned E. coli lacZ gene.
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