Hermann Muller and the Drosophila ClB Chromosome Method

Cross l: 9 ClBI+ a Wild type (X-ray exposed) X- -Rays 5 + CIB x m(?) Bar eye I ___________F______________ema les Males CBI'I m(?)and +|l m(?) + l€and CIB|€ Bar eye Wild type Wild type Dies Cross ll: 9 CIB/m(?) 6' Wild type CIB m(?) x + '67 Cross ll progeny possibility 1 lf no lethal mutation is induced by X-irradiation, 3:2 1 ratio of 9: d' isexpected r ”Mm Females Males CIB lI-I- and m(?) 'I + m(?) lgand CIB '6 Bar eye Wild type Wild type Dies or mutant Cross II progeny possibility 2 Alternatively, if lethal mutation is induced, hemizygous m(?)/Y males die and only female progeny are produced. i Females Males CIB ll+ and m(?) ll + m(?) lfiand CIB '6 Bar eye Wild type Dies Dies (mutation carrier) Additional study and possible characterization of the induced lethal mutation