Evolution of the vertebrate SR gene family

Multiple duplications of the ancestral estrogen receptor gene AncSR1 were followed by diversification to produce two vertebrate estrogen receptors (ERs) and other ERs. Other vertebrate steroid receptors (MR, GR, PR, and AR) evolved to use intermediates in the estrogen biosynthetic pathway as ligandsMultiple duplications of the ancestral estrogen receptor gene AncSR1 were followed by diversification to produce two vertebrate estrogen receptors (ERs) and other ERs. Other vertebrate steroid receptors (MR, GR, PR, and AR) evolved to use intermediates in the estrogen biosynthetic pathway as ligands

Estrogen receptor WWW Vertebrate MR Vertebrate GR Vertebrate PR WWW Vertebrate AR v» Cephalochordate SR AncS R1 m Other receptorclade H