Hemophilia A in the royal families of Europe

The disease in these families originated with a de novo mutation in Queen Victoria. Note that some parents are omitted from the pedigree for clarity. In all cases, these individuals carry and contribute wild-type allelesThe disease in these families originated with a de novo mutation in Queen Victoria. Note that some parents are omitted from the pedigree for clarity. In all cases, these individuals carry and contribute wild-type alleles

' Edward Victoria Duke of Kent Princess of Saxe-Coburg Victoria Queen of England (de novo mutation) mama Victoria Frederick Edward Vll Leopold of of Germany England 'v u George V Irene Henry of Alix Nikolas ll Alice Prussia of Russia V i o I b a a, In Q Q2» $ VI 0 0 Margaret Elizabeth II Juan Carlos of Spain E Normal male . Spanish V” O Normalfemale royal family Andrew Edward I Affected male VIIl © Carrier female Peter Zara Kate William Harry Beatrice Eugenie Possuble carrier female lX George Charlotte British royal family (No affected descendants)