(a) DNA-binding proteins forming an HTH motif are usually dimeric. Two subunits of an HTH dimer are shown as pairs of helices joined by a “turn” connecting them. The recognition helices bind DNA that often is composed of inverted repeat sequence in the major or minor grooves. The stabilizing helices interact with one another to help hold the complex together. (b) Inverted repeat sequences are often targets of DNA-binding regulatory domains of proteins such as HTH proteins(a) DNA-binding proteins forming an HTH motif are usually dimeric. Two subunits of an HTH dimer are shown as pairs of helices joined by a “turn” connecting them. The recognition helices bind DNA that often is composed of inverted repeat sequence in the major or minor grooves. The stabilizing helices interact with one another to help hold the complex together. (b) Inverted repeat sequences are often targets of DNA-binding regulatory domains of proteins such as HTH proteins
