Acetylation and deacetylation in open and closed chromatin structure

Histone deacetylases (HDACs) deacetylate amino acids in N-terminal histone protein tails and close the chromatin structure. Histone acetyltransferases (HATs) acetylate N-terminal amino acids and help open the chromatin structure to activate transcriptionHistone deacetylases (HDACs) deacetylate amino acids in N-terminal histone protein tails and close the chromatin structure. Histone acetyltransferases (HATs) acetylate N-terminal amino acids and help open the chromatin structure to activate transcription

0 No transcription o Activator and HAT recruitment Activator-protein binding recruits HAT complex; histones acetylated. 9 Transcription activated Activator __ RNA pol "le fli; e 9 s? 9 9 QRepressor and HDAC Repressor protein recruits HDAC; histones deacetylated. recruitment RNA poi Ii —inding initiates tra —scription.