The X-inactivation center (XIC)

The XIC contains Xist, which is transcribed to produce a specialized RNA that coats the X chromosome. This mechanism is responsible for random inactivation in eutherian mammalsThe XIC contains Xist, which is transcribed to produce a specialized RNA that coats the X chromosome. This mechanism is responsible for random inactivation in eutherian mammals

Heterochromatic X chromosome XIC (X—inactivation center) l—% g= L.‘ Xlst (X-inactivation-specific transcript) Xist activation and ‘ recruitment of Xist RNA lto locations throughout 3the chromosome to be 3 inactivated Stable X/‘st RNA coats the X chromo- some ‘ Coat of Xist RNA leads to 7 3 3 a...“ 3 silencing and condensa— k‘usb LSD-WWLYMild 3 . 3 tion of X chromosome. HMTs are attracted to RNA coating; H3 and H4 histories are deacetylated and methylated, inactivating the chromosome. Condensed and silenced X chromosome forms a l l 3 Barr body.