Down syndrome  is caused by a triple copy of chromosome 21, which leads to a number of cognitive and physical delays. Now researchers from the Sanford-Burnham Medical Research Institute in La Jolla, California, have found a protein that restores the some of the cognitive and behavioral disorders found in the disease.

Mice who were deficient in the SNX27 protein exhibited similar characteristics to mice with Down syndrome—namely, they had fewer glutamate receptors, which are important for learning and memory, the team reported in Nature Medicine on Sunday (March 24). The researchers also showed that in mice with Down syndrome, the protein is blocked by a molecule encoded on chromosome 21, and produced in excess in Down syndrome mice as a re ...

Varicose veins in a patient's lower leg. The veins, which carry blood back to the heart, are swollen, irregular and distorted. Varicose veins are most common in the legs, but may also be found in the oesophagus or testis. They occur when valves, which usually prevent the backflow of blood and support the pressure from the blood above, become leaky. The veins then stretch and bulge. Support stockings are usually used to treat the condition, although in some cases surgery is needed to remove the veins. Pregnancy, being overweight, and standing for long periods, all increase the risk of varicose veins. ...