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Home Q & A Board Biology-Related Homework Help Cell Biology
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colleen colleen
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12 years ago
Cancer cells metastasize due to a variety of interactions with cell adhesions, cell junctions, and the extracellular matrix. Explain how cancer cells metastasize by three different mechanisms via cellular adhesion, cell junctions, and the extracellular matrix.
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Sunshine ☀ ☼

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12 years ago
There are a variety of causes for cancer cell metastasis. However, in keeping with the theme of this chapter, answers may include the following: the cells stop producing E-cadherin or other cadherins; an increase in MMP activity; an increased ability to bind the basal lamina; the inability to synthesize fibronectins, resulting in a loss of shape and detachment from the ECM; focal adhesion unresponsiveness beta-catenin function in the Wnt signalling pathway associated with cancer; etc.
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