An older adult woman has been diagnosed with acute lymphoblastic leukemia (ALL) and her care team ...

An older adult woman has been diagnosed with acute lymphoblastic leukemia (ALL) and her care team has identified potential benefits of imatinib.
 
  Which of the following characteristics of this patient's current health status may preclude the use of imatinib?
  A) The patient has type 2 diabetes mellitus that is controlled using diet and oral antihyperglycemics.
  B) The patient has chronic heart failure resulting in significant peripheral edema.
  C) The patient experienced a mild ischemic stroke several years ago and had transient ischemic attacks last year.
  D) The patient had a total knee arthroplasty several months earlier.