The nurse evaluates a client taking a high daily dose of duloxetine (Cymbalta) for which signs and ...

Correct Answer: 1, 3, 4

Rationale 1: Suicidal ideation is possible because Cymbalta can cause suicidal ideation.
Rationale 2: Cymbalta causes sexual dysfunction.
Rationale 3: Liver failure is possible because Cymbalta causes liver toxicity at high doses.
Rationale 4: Seizures are possible because Cymbalta lowers seizure threshold at high doses.
Rationale 5: Hypotension is not likely with a high dose of Cymbalta.

Global Rationale: Suicidal ideation is possible because Cymbalta can cause suicidal ideation. Cymbalta causes sexual dysfunction. Liver failure is possible because Cymbalta causes liver toxicity at high doses. Seizures are possible because Cymbalta lowers seizure threshold at high doses. Hypotension is not likely with a high dose of Cymbalta.