Di hybrid Cross, basic genetics?

Blood type:  
Man   IA IB x i i   Woman =>
1/2 type IA
1/2 type IB
(both get an i from mom, so only dad's allele determines blood type)

Color blindness is X-linked Recessive, and mom must be heterozygous bc grandma was colorblind:

  Mom  Xb XB  x   Xb Y  Dad =>
1/4 Xb Xb (colorblind daughter)
1/4 XB Xb (daughter with normal vision)
1/4 Xb Y   (Colorblind son)
1/4 XB Y - (son with normal vision)

I would set it up as two separate Punnet Squares, the multiply the individual probabilities:

 16 children x 1/4 colorblind son x 1/2 blood type A