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Home Q & A Board Biology-Related Homework Help Cell Biology
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rkearl27 rkearl27
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11 years ago
You have discovered a nuclease that has been shown to degrade mRNAs from the 5' end. You expose equal amounts of politase mRNA to two separate samples of the nuclease. One of the mRNAs has an intact 5'-methylguanosine cap; the other has had the cap removed. Which mRNA is most susceptible to attack by this nuclease?
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#1
11 years ago
The uncapped mRNA is more susceptible.  the 5'cap is linked to the mRNA by a triphosphate linkage 5' site to 5' site.  This type of binding creates a less favorable 5' end  for the nuclease (it's catalytic site can't chew up mRNA with this structure on it) to function making it less susceptible to degredation.
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