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Home Q & A Board Biology-Related Homework Help Cell Biology
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adhungan adhungan
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9 years ago
Describe a way that scientists can use to determine if a protein is located on the exoplasmic face of the cell membrane. 

Please helppp !!
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wrote...
#1
Educator
9 years ago
Start with this definitions:

Exoplasmic face

You're asking, what characteristics would a peptide have in order to be in the exoplasmic face - I'm not sure Face with Stuck-out Tongue

I did find this information that might help --

Quote
Many such proteins contain a single membrane-spanning segment: a sequence of 20 – 25 hydrophobic amino acids that forms a transmembrane α helix, anchoring the protein in the phospholipid bilayer. Most of these single-pass transmembrane proteins have their hydrophilic N-terminal segment on the exoplasmic face and their hydrophilic C-terminal segment on the cytosolic face; other single-pass proteins have the reverse orientation. Many plasma-membrane proteins have multiple membrane-spanning α-helical segments. Such multi- pass transmembrane proteins include the glucose transporter GLUT1 and numerous G protein – linked cell-surface receptors. Still other membrane proteins, which lack a hydrophobic membrane-spanning segment, are linked to a glycosylphosphatidylinositol (GPI) anchor that is embedded in the phospholipid bilayer.
Source  http://www.ncbi.nlm.nih.gov/books/NBK21731/
adhungan Author
wrote...
#2
9 years ago
Quote from: bio_man (9 years ago)
Start with this definitions:

Exoplasmic face

You're asking, what characteristics would a peptide have in order to be in the exoplasmic face - I'm not sure Face with Stuck-out Tongue

I did find this information that might help --


I need the method that scientist use to find where the proteins are located. As in the explasmic face of cell membrane.

Quote
Many such proteins contain a single membrane-spanning segment: a sequence of 20 – 25 hydrophobic amino acids that forms a transmembrane α helix, anchoring the protein in the phospholipid bilayer. Most of these single-pass transmembrane proteins have their hydrophilic N-terminal segment on the exoplasmic face and their hydrophilic C-terminal segment on the cytosolic face; other single-pass proteins have the reverse orientation. Many plasma-membrane proteins have multiple membrane-spanning α-helical segments. Such multi- pass transmembrane proteins include the glucose transporter GLUT1 and numerous G protein – linked cell-surface receptors. Still other membrane proteins, which lack a hydrophobic membrane-spanning segment, are linked to a glycosylphosphatidylinositol (GPI) anchor that is embedded in the phospholipid bilayer.
wrote...
#3
Educator
9 years ago
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DrDolittleDrDolittle
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#4
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9 years ago Edited: 9 years ago, DrDolittle
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