1. Tobacco Smoke
Scientists are working hard to learn about causes of cancer. It is known that in general terms, cancer-causing agents produce mutations in a variety of genes that control cell reproduction.
Cancer can be caused by organisms. For example, when some viruses infect a human cell, the virus DNA inserts itself randomly into the DNA of human cells.
Of all the cancer-causing agents to which humans are commonly exposed, tobacco smoke appear to cause the greatest harm. Tobacco is directly responsible for 30% of all cancer deaths in North America. Heavy smoking increases the likelihood of getting lung cancer by 2000%. Passive (second-hand) smoke is less likely to cause cancer. It is about as harmful as all other forms of air pollution.
- from Trichopoulos, Li, and Hunter, 1996
A researcher wants to develop a study to help determine what percentage of smokers will die from cancer caused by tobacco and its smoke. The researcher gathers two groups of subjects and observes them over a long period of time.
Identify the manipulated variable and the responding variable for the study.
2. Antimetabolites
Antimetabolites are a form of chemotherapy drug. Antimetabolites are substitutes for the building blocks of DNA and RNA. These drugs damage cancer cells during the S phase of the cell cycle.
a)Describe the stages of the cell cycle.
b)Use knowledge of the cell cycle to explain why antimetabolites would be an effective form of cancer treatment.
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