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colleen colleen
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Posts: 17076
13 years ago
Describe the establishment and maintenance of the lysogenic state in the lambda phage.
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13 years ago
Lambda phage, once circularized by matching its cohesive ends, integrates into an E. coli host genome by targeting the att(lambda) gene in the host genome. The att gene in lambda's genome then base pairs with the complementary sequences found in the at(lambda) gene, and the lambda genome is inserted in the presence of an integrase catalyst. After the lambda genome is established in the host's genome, it is maintained along with the E. coli genome through replication.
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