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What is a limitation of using L-dopa for Parkinson's disease?

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What is a limitation of using L-dopa for Parkinson's disease?

What is a limitation of using L-dopa for Parkinson's disease?

a. It only helps those who are in the later stages.
b. It does not cross the blood-brain barrier.
c. It can contribute to a greater loss of dopamine neurons.
d. It blocks glutamate receptors.

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Thank you, thank you, thank you!

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