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cdong cdong
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6 years ago
Explain how autoradiography can be used to measure the activity of brain cells.
 
  What will be an ideal response?
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6 years ago
Answer: Brain cells require glucose as fuel for activity. 2-DG , like glucose, is taken up into neurons, but cannot be used for energy. If a radioactive version of 2-DG is injected into an animal, radioactive 2-DG molecules will accumulate in brain as a function of the relative activity of those cells. Autoradiography will reveal the presence of radioactive molecules in the brain, with a more intense signal in regions that were more active, and a less intense signal in less active regions.
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