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colleen colleen
wrote...
Valued Member
Posts: 17077
12 years ago
Describe the docking and fusion of vesicles with the cell membrane. How do tetanus toxin and botulinum toxin work to interfere with this process?
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Sunshine ☀ ☼

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wrote...
12 years ago
This, you answer needs to include a description of the action potential reaching the synaptic bouton; an influx of calcium ions; synaptotagmin mediation of the calcium ions and v- and t-SNARE interaction at the active zone; vesicle fusion and kiss-and-run exocytosis. Tetanus toxin prevents the release of neurotransmitters from inhibitory neurons in the spinal cord, resulting in uncontrolled muscle contraction. Botulinum toxin prevents the release of neurotransmitters from motor neurons, resulting in muscle weakness and paralysis.
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