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Home Q & A Board Biology-Related Homework Help Cell Biology
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dank88 dank88
wrote...
10 years ago
You have generated a knockout mouse that does not express CD40.  Upon stimulation with a T-dependent antigen, do you expect this mouse to be able to:

Secrete IgG antibodies specific for your antigen?


Secrete antigen-specific antibodies that have undergone class switching?


Thank you.
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wrote...
#1
Staff Member
Educator
10 years ago
CD40 is a co-stimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on T=helper cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
Mastering in Nutritional Biology
Tralalalala Slight Smile
dank88 Author
wrote...
#2
10 years ago
Thank you!
wrote...
#3
Staff Member
Educator
10 years ago
NP
Mastering in Nutritional Biology
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