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agilleland agilleland
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6 years ago
Discuss the importance of the bone marrow stroma for B-cell development.
 
  http://science-forums.com/index.php?action=webForm;done
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6 years ago
Bone marrow stromal cells provide the necessary environment for B-cell development by expressing secreted products and membrane-bound adhesion molecules. For example, VCAM-1 adhesion molecule binds to the integrin VLA-4 on early B-cell progenitors. Cytokines such as IL-7 have an important role in later stages of B-cell development, serving to stimulate the growth and cell division of late pro-B and pre-B cells.
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