Aspirin has which adverse effect on the gastrointestinal mucosa? 1. Aspirin causes direct ...

Correct Answer: 1
Rationale 1: Aspirin causes topical damage to the stomach as it crosses the mucosa. This direct cellular injury can result in GI bleeding.
Rationale 2: Not all aspirin products are enteric-coated.
Rationale 3: Aspirin inhibits COX-1 once it is systemically absorbed; it depletes the GI mucosa of prostaglandin.
Rationale 4: Aspirin depletes the GI mucosa of prostaglandins.
Global Rationale: As aspirin is absorbed across the stomach mucosa, it causes direct cellular injury. This topical damage to the stomach may be lessened by the use of enteric-coated formulations. After aspirin is absorbed systemically, it inhibits COX-1 and depletes the GI mucosa of prostaglandins which normally provide a protective function by directing the secretion of mucus and bicarbonate and promoting cellular repair of mucosal damage. Not all aspirin products are enteric-coated.

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