A client asks the nurse why a medication prescribed by the provider didn't do anything at all. ...

Correct Answer: 1,2,3
Rationale 1: 99.8 of human DNA sequences are identical. The remaining 0.2 can account for significant differences in people's ability to handle medications.
Rationale 2: The structure of an enzyme is closely related to its function. A mutation can cause a change in the structure of the enzyme, resulting in a change in its function.
Rationale 3: When enzymes are functionally changed by genetics, metabolism and excretion can be altered, resulting in the drug either accumulating or being inactivated.
Rationale 4: Small changes in the structure of a protein may result in a defective receptor that will not accept the drug and the drug not having any therapeutic effect.
Rationale 5: Genetic differences can result in mutations of enzymes or proteins, which may result in changes in function. Being of a certain race may predispose a client to mutations and, therefore, uncommon responses to medication, but this does not mean the client will have an allergic response to medications.
Global Rationale: 99.8 of human DNA sequences are identical. The remaining 0.2 can account for significant differences in people's ability to handle medications. The structure of an enzyme is closely related to its function. A mutation can cause a change in the structure of the enzyme, resulting in a change in its function. When enzymes are functionally changed by genetics, metabolism and excretion can be altered, resulting in the drug either accumulating or being inactivated. Small changes in the structure of a protein may result in a defective receptor that will not accept the drug and the drug not having any therapeutic effect. Genetic differences can result in mutations of enzymes or proteins, which may result in changes in function. Being of a certain race may predispose a client to mutations and, therefore, uncommon responses to medication, but this does not mean the client will have an allergic response to medications.