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Home Q & A Board Biology-Related Homework Help Medicine
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unnicole unnicole
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6 years ago
The nurse assumes care for an infant who is showing signs of drug toxicity to a drug given several hours prior. The nurse checks the dose and confirms that the dose is consistent with standard dosing guidelines.
 
  Which characteristic of the drug will likely explain this response in this patient?
  a. It is acidic.
  b. It is highly protein-bound.
  c. It is not fat-soluble.
  d. It is water-soluble.
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#1
6 years ago
ANS: B
With fewer protein-binding sites, there is more active drug available. This requires a reduction in the dose for infants. Drugs that are acidic are not as readily absorbed in infants, since their gastric pH tends to be more alkaline. Infants have a lower proportion of body fat; fat-soluble drugs would need to be decreased to prevent toxicity. Until about age 2 years of age, pediatric patients require larger than usual doses of water-soluble drugs to achieve therapeutic effects.
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