Two nurses are discussing drugs that are affected by the first-pass effect. The nurses understand ...

D
Nitroglycerin given orally is subject to the first-pass effect because most of it is destroyed by the liver; therefore, this medication should not be given orally.
An intravenous medication cannot be subject to the first-pass effect.
Nitroglycerin given sublingually is not subject to the first-pass effect, therefore the most effective route for administration of nitroglycerin is the sublingual route.
A drug given sublingually is not subject to the first-pass effect.

DIF: Cognitive Level: Application REF: p. 39
TOP: Nursing Process: Assessment
MSC: NCLEX Client Needs Category: Physiological Integrity: Pharmacological and Parenteral Therapies

Makes a ton more sense now