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lpooziee lpooziee
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6 years ago
Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these types of reactions is to:
 
  1. Inactivate prodrugs before they can be activated by target tissues
  2. Change the drugs so they can cross plasma membranes
  3. Change drug molecules to a form that an excretory organ can excrete
  4. Make these drugs more ionized and polar to facilitate excretion
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