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Home Q & A Board Biology-Related Homework Help Medicine Nursing and Clinical
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Nalu Nalu
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6 years ago
Hemolytic disease of the newborn due to the maternal-fetal blood group incompatibility represents which form of hypersensitivity?
 
  A. type I
  B. type II
  C. type III
  D. type IV
  E. graft-versus-host reaction
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#1
6 years ago
B
Hemolysis due to maternal-fetal incompatibility represents a type II hypersensitivity reaction. In classic cases the red blood cells of an Rh(+) fetus/infant are destroyed by anti-Rh antibodies in a Rh() mother sensitized to Rh(+) antigen in a previous pregnancy. Binding of the cytotoxic maternal antibodies to fetal red blood cells activates complement, which forms the membrane attacked complex (MAC) perforating the red blood cell membrane.
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