1) what is QTL ? which diseases have QTL ?
Quantitative trait loci are regions of the genome at which genetic variation is associated with a particular quantitative trait - for example, height, weight or blood pressure. Quantitative trait loci are identified by showing a statistical association between genetic markers and measurable phenotypes.
2) What is SNP RFLP and whats is there relationship ?
A Single Nucleotide Polymorphism is a DNA sequence variation occurring commonly within a population in which a Single Nucleotide — A, T, C or G — in the genome differs between members of a biological species or paired chromosomes.
Restriction Fragment Length Polymorphism (RFLP) is a difference in homologous DNA sequences that can be detected by the presence of fragments of different lengths after digestion of the DNA samples in question with specific restriction endonucleases. RFLP, as a molecular marker, is specific to a single clone/restriction enzyme combination.
SNPs can create or abolish restriction endonuclease (RE) recognition sites, thus affecting quantities and length of DNA fragments resulting from RE digestion.
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