Describe the monoamine hypothesis of depression and discuss evidence that suppor

Depression (without mania) reflects profound changes in mood, appetite, movement, and sleep. The monoamine hypothesis argues that depression reflects a reduced level of activity of the monoamine transmitters, specifically norepinephrine (NE) and serotonin (5-HT). Reserpine treatment depletes monoamine levels in the brain and can result in depression. A variety of treatments exist for unipolar depression (MAOI, tricyclics, serotonin reuptake inhibitors, ECT, sleep deprivation). The tricyclic drugs block the reuptake of NE and 5-HT while the serotonin reuptake inhibitors block only serotonin reuptake (resulting in more serotonin). Low levels of 5-HIAA are associated with attempts at suicide.

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