Give two pieces of evidence that support the monoamine hypothesis of depression and one piece of ...

The actions and behavioral effects of reserpine (depletes monoamines, reduces manic symptoms, induces depression), MAOIs (allow cytoplasmic concentrations of monoamines to increase, reduce symptoms of depression), amphetamine (increases extraneuronal monoamine levels, enhances mood), and monoamine reuptake blockers (increase extraneuronal monoamine levels, reduce symptoms of depression) are superficially compatible with the hypothesis, but the fact that MAOIs and many antidepressants enhance monoamine levels within hours but exert their benefits in depressed individuals over several days or weeks is a problem for the hypothesis. Also, clinically effective antidepressants only elevate mood in depressed individuals. Also, treatments that acutely deplete the brain of NE or 5-HT in normal adults without a history of depression do not induce the core symptoms of depression.