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Home Q & A Board Biology-Related Homework Help Cell Biology
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Martini306 Martini306
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6 years ago
As the most junior member of a lab, you are tasked with generating cell lines that accumulate DNA damage to investigate how random mutations affect transformation of cells into cancer cells.
 
  You decide to mutate proteins in the p53 pathway. Which three proteins would you mutate? Explain your reasoning.
  What will be an ideal response?
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6 years ago
Answer: p53Destroying the activity of p53 blocks the entire DNA damage response pathway. Cells lacking p53 are unable to respond to DNA damage by arresting the cell cycle or stimulating cell division.
ATM/ATRDNA damage activates ATM/ATR to initiate the pathway in which stabilized p53 stimulates production of p21, which arrests the cell cycle by preventing G1 Cdk-cyclin phosphorylation of Rb.
p21A nonfunctional p21 would be unable to arrest G1 Cdk-cyclin Rb phosphorylation and stop the cell cycle.
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