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Large cells with abundant, intensely basophilic cytoplasm with prominent cytoplasmic vacuolization ...

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Large cells with abundant, intensely basophilic cytoplasm with prominent cytoplasmic vacuolization ...

Large cells with abundant, intensely basophilic cytoplasm with prominent cytoplasmic vacuolization are identified on a peripheral smear. Multiple basophilic nucleoli are present.

A starry sky appearance is seen with fields of basophilic leukemic blasts with benign macrophages that have ingested tumor cells. What leukemia should be suspected with this morphology?

a. Acute undifferentiated leukemia
b. Acute lymphoblastic leukemiaBurkitt-type
c. Acute leukemia with lineage heterogeneity
d. Precursor T-cell leukemia

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