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litty 123 litty 123
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6 years ago
Reverse transcriptase, the enzyme responsible for copying viral RNA into cDNA prior to integration into the host genome, lacks 3'-to-5' exonuclease proofreading ability. How is this advantageous to organisms that depend on such enzymes?
 
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6 years ago
Retroviruses depend on reverse transcriptase. Part of the successful infection and proliferation strategy of retroviruses like HIV is their high mutability. The errors made by the enzyme are useful in generating variable progeny viruses that can evade the host's immune system.
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