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mehdido712 mehdido712
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7 years ago
In cancer cells one allele of the tumor suppressor gene p53 is frequently mutated so that the protein is inactive, not produced, or deleted.
 
  The other allele will usually have a normal sequence and the promoter remains intact but the gene is not expressed. Sequencing with sodium bisulfite modification of DNA can be used to detect which cytosines are methylated. If the cancer cell DNA is sequenced what would be the anticipated results?
 
 A. Cytosines in or near the promoter region will be methylated
  B. Cytosines in or near the promoter will not be methylated
  C. Cytosines in the coding region will have an increased mehtylation
  D. There will be no differences in the methylation pattern of the promoter of p53 from a cancer cell and a normal cell
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