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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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Kfields37 Kfields37
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6 years ago
A 2-month-old is diagnosed with Hirschsprung disease with the resulting development of a megacolon. What is the most likely cause of this condition?
 
  a. Absence of intrinsic ganglion cells result-ing in impaired peristalsis
  b. The use of cow's milk instead of formula
  c. Excessive use of glycerin suppositories to promote bowel elimination
  d. Additional ganglion cells throughout the length of the colon
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6 years ago
ANS: A
Congenital aganglionic megacolon is caused by the absence of the intrinsic ganglion cells (sub-mucosal and myentric plexuses) along a variable length of the colon, resulting in inadequate peri-staltic movement in the bowels. The resulting distention of the proximal colon results in the term megacolon. Megacolon is a functional anatomic disorder not related to formula or use of suppos-itories.
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